Description
The transmembrane protein (such as a mechanosensitive ion channel, MscL) has been modeled as a transmembrane inclusion that changes the membrane thickness around it. In this study, we couple the dynamics of a vesicle under a planar flow to the transmembrane inclusion and examine how the line tension around the inclusion varies with different vesicle dynamics, such as tank-treading and tumbling, under a flow. These results help interpret the correlation between red blood cell dynamics and the ATP release due to mechanotransduction. Furthermore, the effect of electric field on a vesicle with a protein inclusion is investigated.
Recommended Citation
Young, Y. (2014). Coupling the vesicle dynamics to a transmembrane inclusion. In A. Bajaj, P. Zavattieri, M. Koslowski, & T. Siegmund (Eds.). Proceedings of the Society of Engineering Science 51st Annual Technical Meeting, October 1-3, 2014 , West Lafayette: Purdue University Libraries Scholarly Publishing Services, 2014. https://docs.lib.purdue.edu/ses2014/mfts/mvc/10
Coupling the vesicle dynamics to a transmembrane inclusion
The transmembrane protein (such as a mechanosensitive ion channel, MscL) has been modeled as a transmembrane inclusion that changes the membrane thickness around it. In this study, we couple the dynamics of a vesicle under a planar flow to the transmembrane inclusion and examine how the line tension around the inclusion varies with different vesicle dynamics, such as tank-treading and tumbling, under a flow. These results help interpret the correlation between red blood cell dynamics and the ATP release due to mechanotransduction. Furthermore, the effect of electric field on a vesicle with a protein inclusion is investigated.