Mechano-biology of Cells and Tissues: Emergent Behavior in Adaptation, Growth and Remodeling

In recent years, an increasing number of studies have shown that mechanical interactions between cells and their surrounding tissue are key to macroscopic tissue growth, remodeling, as well as cell differentiation. It is now clear that cells fully make use of cross-talks between mechanics and chemistry to sense and subsequently remodel their surroundings by applying forces and growing new matrix. The origins of these intriguing behaviors are however poorly understood, hindering current strategies to control tissue growth and morphogenesis in the lab. The goal of this broad symposium is to bring together speakers from the applied mechanics, bioengineering and medical community to discuss the latest experimental, theoretical and computational developments to understand the role of mechanics in the emergent behavior of tissues (adaptation, growth and remodeling) from the cellular to the macro-scale. Topics of interest include but are not limited to: cell adhesion and mechano-sensing, cytoskeletal dynamics, cell-matrix interactions as well as tissue growth, remodeling and morphogenesis.

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Schedule
	3D traction forces of Schwann cells on compliant substrates Eyal Bar-Kochba, Brown University
	Biological ferroelectricity – phenomena, mechanism, and implications Jiangyu Li, University of Washington, United States
	Cells as strain-cued automata Brian Cox, Teledyne Scientific
	Chemoenvironmental modulators of single-cell fluidity and stiffness John Maloney, MIT, United States Krystyn Van Vliet, MIT, United States
	Compression of fibrin networks modeled as a foam Prashant Purohit, University of Pennsylvania, USA
	Computational modeling of biomechanics: biological growth and morphogenesis Jiaoyan Li, The George Washington University, United States Lijie Zhang, The George Washington University, United States James Lee, The George Washington University, United States
	Coupled Eulerian–Lagrangian extended finite element approach to simulating the mechanics and growth of biofilm, cells, and tissues Ravindra Duddu, Vanderbilt University, United States Anup Aryal, Vanderbilt University, United States Louis Foucard, University of Colorado, Boulder, United States Franck Vernerey, University of Colorado, Boulder, United States
	Elucidating the mechanics of clathrin-mediated endocytosis Ashutosh Agrawal, University of Houston, United States Nikhil Walani, University of Houston, United States Jennifer Torres, University of Houston, United States
	GPCRs receptors prefer lipid rafts Laura Lunghi, University of Ferrara, Italy Pietro Pollaci, University of Trento, Italy Luca Deseri, University of Trento, Italy
	Growth mechanics in degradable hydrogel scaffolds Franck Vernerey, University of Colorado, United States
	In package inactivation of Bacillus atrophaeus spores using high voltage atmospheric cold plasma Sonal Patil, Purdue University, Nelson Hall of Food Science, West Lafayette, IN, USA Kevin Keener, Purdue University, Nelson Hall of Food Science, West Lafayette, IN, USA Tamara Moiseev, School of Physical Sciences and National Centre for Plasma Science and Technology, Dublin City University, Glasnevin, Dublin 9, Ireland JP Mosnier, School of Physical Sciences and National Centre for Plasma Science and Technology, Dublin City University, Glasnevin, Dublin 9, Ireland NN Misra, School of Food Science and Environmental Health, Dublin Institute of Technology, Cathal Brugha Street, Dublin 1, Ireland PJ Cullen, School of Food Science and Environmental Health, Dublin Institute of Technology, Cathal Brugha Street, Dublin 1, Ireland Paula Bourke, School of Food Science and Environmental Health, Dublin Institute of Technology, Cathal Brugha Street, Dublin 1, Ireland
	Long range cell‑cell interactions through substrate strain fields M Taher Saif, University of Illinois at Urbana-Champaign Brian Williams, United States
	Mechanism of cell alignment in Myxococcus xanthus groups Rajesh Balagam, Rice University, United States Oleg Igoshin, Rice University, United States
	Mechanosensitive response of voltage-gated ion channels Ashutosh Agrawal, University of Houston, United States Vikash Chaurasia, University of Houston, United States Kranthi Mandadapu, University of California, Berkeley, United States
	Microcavitation as a neuronal damage mechanism in blast -traumatic brain injury Jon Estrada, Brown University, United States Christian Franck, Brown University, United States
	Microtubule-driven conformational changes in platelet -morphogenesis Wylie Stroberg, Northwestern University, United States Wing Kam Liu, Northwestern University, United States Seth Lichter, Northwestern University, United States
	Molecular origins of the loss of deformability in Plasmodium -falciparum infected erythrocytes: a coarse-grained modeling Yao Zhang, Department of Engineering Science and Mechanics, The Pennsylvania State University, PA 16801, USA Changjin Huang, Department of Engineering Science and Mechanics, The Pennsylvania State University, PA 16801, USA Mahdi Golkaram, Department of Engineering Science and Mechanics, The Pennsylvania State University, PA 16801, USA Sulin Zhang, Department of Engineering Science and Mechanics, The Pennsylvania State University, PA 16801, USA
	Stress-fiber mechanics and cell mechano-sensitivity Franck Vernerey, University of Colorado, United States
	TEM observations of cytoskeletal evolution in CNS axons Adam Fournier, Johns Hopkins University, United States Labchan Rajbhandari, Johns Hopkins University, United States Shiva Shrestha, Johns Hopkins University, United States Arun Venkatesan, Johns Hopkins University, United States K. T. Ramesh, Johns Hopkins University, United States James Hogan, Hopkins Extreme Material Institute, United States
	Time varying cell forces – a new paradigm in cellular mechanotransduction M Taher Saif, University of Illinois at Urbana-Champaign, United States Samantha Knoll, United States
	Trans-disciplinary research approaches: integration of fluid mechanics with cell biology Michelle A. Berny-Lang, Office of the Director, National Cancer Institute, National Institutes of Health, United States Jerry S.H. Lee, Office of the Director, National Cancer Institute, National Institutes of Health, United States Emily J. Greenspan, Office of the Director, National Cancer Institute, National Institutes of Health, United States

Society of Engineering Science 51st Annual Technical Meeting

Mechano-biology of Cells and Tissues: Emergent Behavior in Adaptation, Growth and Remodeling

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