Abstract
Cells are the fundamental building block of complex tissues in higher-order organisms. These cells take different forms and shapes to perform a broad range of functions. What makes a cell uniquely eligible to perform a task, however, is not well-understood; neither is the defining characteristic that groups similar cells together to constitute a cell type. Even for known cell types, underlying pathways that mediate cell type-specific functionality are not readily available. These functions, in turn, contribute to cell type-specific susceptibility in various disorders.
Keywords
Cell type, Interactome, Tissue, Transcriptome
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Computer Science
First Advisor
Ananth Grama
Second Advisor
Wojciech Szpankowski
Committee Member 1
David Gleich
Committee Member 2
Jennifer Neville
Committee Member 3
Markus Lill
Date of Award
January 2016
Recommended Citation
Mohammadi, Shahin, "Cell Type-specific Analysis of Human Interactome and Transcriptome" (2016). Open Access Dissertations. 1371.
https://docs.lib.purdue.edu/open_access_dissertations/1371