Abstract
A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is shown to successfully reproduce a number of experimentally determined fibril structures.
Keywords
Amyloid fibril, Fibrilation, Glucogon, Peptide formulation, Protein structure, Statistical potential
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Medicinal Chemistry and Molecular Pharmacology
First Advisor
Markus A Lill
Second Advisor
Elizabeth M Topp
Committee Member 1
Carol B Post
Committee Member 2
Chiwook Park
Committee Member 3
Daisuke Kihara
Date of Award
January 2015
Recommended Citation
Tabatabaei Ghomi, Hamed, "COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON" (2015). Open Access Dissertations. 1321.
https://docs.lib.purdue.edu/open_access_dissertations/1321