Date of Award
January 2016
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Garth J Simpson
Committee Member 1
Mary J Wirth
Committee Member 2
Chittaranjan Das
Committee Member 3
Lynne S Taylor
Abstract
The crystalline form of a solid can profoundly affect its physical and chemical properties, with both potentially stable and metastable crystal polymorphs are accessible during crystal formation. Conventional methods limit the detection of rare nucleation and rapid phase transitioning events due to their lack of selectivity and sensitivity. Inkjet printing of a solution confines the nucleation event in a few micrometer volumes within the droplet, and furthermore rapid desolvation favors the kinetic factor to trap the rare metastable polymorphs. Second harmonic generation microscopy (SHG) possesses enough sensitivity to detect sub-micrometer size chiral crystals selectively and has the potential for use in crystal nucleation studies.
Recommended Citation
Chowdhury, Azhad Chowdhury, "UNDERSTANDING AND EVALUATING CRYSTAL POLYMORPHISM BY SECOND HARMONIC GENERATION MICROSCOPY" (2016). Open Access Dissertations. 1210.
https://docs.lib.purdue.edu/open_access_dissertations/1210