Date of Award

January 2015

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Biochemistry

First Advisor

Thomas J Kappock

Committee Member 1

Clint Chapple

Committee Member 2

Barbara Golden

Committee Member 3

Laurie Parker

Abstract

Purines are the basic building block for essential biomolecules such as DNA, RNA, NADH, CoA, and several essential vitamin cofactors. Most organisms have the ability to synthesize purines through the de novo purine biosynthesis pathway.

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