Abstract
Chronic Myelogenous Leukemia (CML) is a hematopoietic cancer caused by the formation of the Philadelphia chromosome, a reciprocal translocation of the ABL1 oncogene on chromosome 9, and the breakpoint cluster region gene (BCR) chromosome 22, resulting in the BCR-ABL oncoprotein. BCR-ABL is a constitutively active tyrosine kinase that regulates cell growth and differentiation, leading to uncontrolled cell proliferation by deregulating downstream signaling pathways.
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Medicinal Chemistry and Molecular Pharmacology
Date of Award
January 2015
Recommended Citation
Noel, Brett, "Proteogenomic Insights Into The Nature Of Chemoresistance In Chronic Myelogenous Leukemia" (2015). Open Access Dissertations. 1136.
https://docs.lib.purdue.edu/open_access_dissertations/1136
First Advisor
Laurie Parker
Committee Member 1
Christine Hyrcyna
Committee Member 2
Tony Hazbun
Committee Member 3
Chiwook Park