Date of Award
January 2015
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Animal Science
First Advisor
Mathew G. Alan
Second Advisor
Paul D. Ebner
Committee Member 1
Haley F. Oliver
Committee Member 2
Marcos H. Rostagno
Abstract
Phage therapy is a promising antibacterial intervention that has received renewed interest in recent years. In this study, the antibacterial efficacy of phage treatments was tested in different food matrices, under different conditions, as well as in both phage cocktail and single phage forms. Additionally, this study also examined phage genome sequences, bacterial phage resistance, and the impact of orally administered phages on acute immune response and gut microbiome of the host in effort to more clearly assess the safety and long-lasting efficacy of phage-based treatments.
Recommended Citation
Hong, Yingying, "Phage therapy applications: Efficacy and impact on the animal intestinal microbiome" (2015). Open Access Dissertations. 1115.
https://docs.lib.purdue.edu/open_access_dissertations/1115