Date of Award

January 2015

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Statistics

First Advisor

Michael Yu Zhu

Committee Member 1

Rebecca W. Doerge

Committee Member 2

Mary Ellen Bock

Committee Member 3

Jun Xie

Abstract

This thesis consists of two main components: a regularization based variable selection method for the single index model and a novel classification based method for DNA methylation status calling for bisulphite-sequencing data.

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