Date of Award
January 2014
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemical Engineering
First Advisor
Julie C. Liu
Committee Member 1
Chongli Yuan
Committee Member 2
Doraiswami Ramkrishna
Committee Member 3
Alyssa Panitch
Abstract
Tissue damage caused by diseases and injuries requires regeneration to recover proper tissue function. Traditional treatments using autologous tissue have not yet met the need for tissue regeneration. Tissue engineering has emerged as an alternative strategy for tissue regeneration. It utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes production and characterization of protein-engineered microenvironments that provide biochemical and biophysical cues to modulate stem cell differentiation.
Recommended Citation
Kim, Yeji, "MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS" (2014). Open Access Dissertations. 1070.
https://docs.lib.purdue.edu/open_access_dissertations/1070