Recommended Citation
Harold, Roslyn; Kelleher, Bridgette; Novak, Keisha; Neo, Wei Siong; Stump, Teagan; Lee, Taylor; Garwood, Tessa; Berry-Kravis, Elizabeth; and Foti, Dan, "Abnormal neural sensitivity to rewards as a candidate process of high depression risk in the FMR1 premutation: A pilot study" (2024). Purdue University Libraries Open Access Publishing Fund. Paper 208.
http://dx.doi.org/10.1016/j.xjmad.2024.100068
DOI
10.1016/j.xjmad.2024.100068
Date of this Version
4-3-2024
Keywords
Event-related potentials, Reward processing, FMR1 premutation, Depression, Fragile X
Abstract
The etiological heterogeneity of depression poses a challenge for prevention and intervention efforts. One solution is to map unique etiological pathways for subgroups defined by a singular risk factor. A relevant population for this approach is women who carry the premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene, who are at high risk for adult-onset depression. This study explores a candidate neurophysiological marker of depression risk: reduced reward sensitivity, indexed by the reward positivity (RewP). The RewP has been linked to depression risk in the general population, but is unexplored within FMR1 premutation carriers. 16 women with the FMR1 premutation and a matched control group completed a simple guessing task while the electroencephalogram was recorded. Among premutation carriers, RewP difference score (win versus loss) was reduced. These preliminary finding suggest that the FMR1 premutation may confer increased risk for depression in part through abnormal neural sensitivity to rewards.
Comments
This is the publisher PDF of Harold, Roslyn et al. (2024) Abnormal neural sensitivity to rewards as a candidate process of high depression risk in the FMR1 premutation: A pilot study. Journal of Mood & Anxiety Disorders 6: 100068. This article is distributed under a CC-BY-NC-ND license, and is available at DOI: 10.1016/j.xjmad.2024.100068.