DOI
10.5703/1288284318529
Description
Comprehending the neural mechanisms underlying Type 2 Diabetes (T2D) is critical to developing next generation bioelectronic therapies. This work-in-progress presents a novel neural interface that integrates edge artificial intelligence (AI), machine learning (ML), and flexible implantable electronics to record, analyze, and modulate vagus nerve activity in real time for potential diabetes treatment and reversal. The proposed system combines low-power, semi-analog signal processing with embedded AI/ML algorithms capable of performing on-chip feature extraction and classification of neural signals under stringent power and communication constraints. By leveraging edge-based learning, the platform will enable adaptive neuromodulation of vagus nerve activity, providing a closed-loop framework for studying the stomach-brain-pancreas signaling involved in diabetes. The edge AI-driven analysis facilitates localized inference and decision-making directly at the neural interface. Validation in small animal models aims to correlate vagal signal dynamics with metabolic states, laying the foundation for energy-efficient, autonomous implants that could support diabetes reversal through intelligent, personalized neural control.
Edge AI-Enabled Vagus Nerve Analysis for Adaptive Neuromodulation in Diabetes
Comprehending the neural mechanisms underlying Type 2 Diabetes (T2D) is critical to developing next generation bioelectronic therapies. This work-in-progress presents a novel neural interface that integrates edge artificial intelligence (AI), machine learning (ML), and flexible implantable electronics to record, analyze, and modulate vagus nerve activity in real time for potential diabetes treatment and reversal. The proposed system combines low-power, semi-analog signal processing with embedded AI/ML algorithms capable of performing on-chip feature extraction and classification of neural signals under stringent power and communication constraints. By leveraging edge-based learning, the platform will enable adaptive neuromodulation of vagus nerve activity, providing a closed-loop framework for studying the stomach-brain-pancreas signaling involved in diabetes. The edge AI-driven analysis facilitates localized inference and decision-making directly at the neural interface. Validation in small animal models aims to correlate vagal signal dynamics with metabolic states, laying the foundation for energy-efficient, autonomous implants that could support diabetes reversal through intelligent, personalized neural control.