Abstract
We present depth-resolved coherence-domain images of living tissue using a dynamic holographic semiconductor film. An AlGaAs photorefractive quantum-well device is used in an adaptive interferometer that records coherent backscattered (image-bearing) light from inside rat osteogenic sarcoma tumor spheroids up to 1 mm in diameter in vitro. The data consist of sequential holographic image frames at successive depths through the tumor represented as a visual video "fly-through." The images from the tumor spheroids reveal heterogeneous structures presumably caused by necrosis and microcalcifications characteristic of human tumors in their early avascular growth. (C) 2003 American Institute of Physics.
Published in:
Applied Physics Letters 83,3 (2003) 575-577;
Link to original published article:
http://dx.doi.org/10.1063/1.1594830#
Keywords
quantum-wells;; turbid media;; tomography
Date of Version
January 2003
Recommended Citation
Yu, P.; Mustata, M.; Turek, J. J.; French, P. M. W.; Melloch, M. R.; and Nolte, D. D., "Holographic optical coherence imaging of tumor spheroids" (2003). Department of Physics and Astronomy Faculty Publications. Paper 365.
https://docs.lib.purdue.edu/physics_articles/365