Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye
Abstract
Fourier-domain holography (FDH) has several advantages over image-domain holography for optical coherence imaging of tissue. Writing the hologram in the Fourier plane significantly reduces background arising from reference light scattered from the photorefractive holographic film. The ability to use FDH is enhanced by the use of a diffuse target, such as scattering tissue, rather than specular targets, because the broader angular distribution from diffuse targets is transformed into a relatively uniform distribution in the Fourier plane. We demonstrate significantly improved performance for Fourier-domain optical coherence imaging on rat osteogenic sarcoma tumor spheroids and mouse eye. The sensitivity is documented at -95 dB. (c) 2005 Optical Society of America.
Published in:
Applied Optics 44,10 (2005) 1798-1805;
Link to original published article:
http://dx.doi.org/10.1364/AO.44.001798
Keywords
multiple-quantum-wells;; turbid media;; photorefractive holography;; tomography;; illumination
Date of Version
1-1-2005
Recommended Citation
Jeong, K.; Peng, L. L.; Turek, J. J.; Melloch, M. R.; and Nolte, D. D., "Fourier-domain holographic optical coherence imaging of tumor spheroids and mouse eye" (2005). Department of Physics and Astronomy Faculty Publications. Paper 172.
https://docs.lib.purdue.edu/physics_articles/172