Date of Award

January 2016

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Industrial and Physical Pharmacy

First Advisor

Yoon Yeo

Committee Member 1

Tonglei Li

Committee Member 2

Rodolfo Pinal

Committee Member 3

Kinam Park

Abstract

Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of ovarian cancer, with the full potential yet to be proven. To facilitate IP chemotherapy of ovarian cancer, we have developed a nanoparticle depot for IP chemotherapy consisted of paclitaxel (PTX) nanocrystals (PNC) and hyaluronic acid-based hydrogel (HA gel). PNC with a size of ~310 nm was produced by nonsolvent and temperature-induced crystallization. Dissolution kinetics of PNC could be determined by the light scattering method rather than the dialysis method due to drug reprecipitation caused by diffusion barrier. PTX release profiles from PNC-gel and PTX precipitate-gel (PPT-gel) were estimated in both sink- and non-sink conditions, where the latter simulated the peritoneal environment. In-vitro release kinetics studies did not reveal any difference between PNC-gel and PPT-gel, partly due to the centrifugation-related artifacts.

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