Date of Award
January 2015
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Mathematics
First Advisor
Gregery T Buzzard
Committee Member 1
Ann E Rundell
Committee Member 2
Robert L Geahlen
Committee Member 3
Zhilan Feng
Abstract
Understanding the immune system and its responses to foreign threats (antigens) is a matter of understanding the immune cells involved, their individual responses, and chemicals responsible for intracellular and intercellular communication. The overall immune response is driven by individual actions of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune cells develop coordinated response while intracellular signals determine responses within a cell; both depend on systems of chemical reactions at their respective scales. The perspective taken in this dissertation is that of understanding B cells at the intracellular scale and the signaling molecules responsible for its responses.
Recommended Citation
McGee, Reginald, "MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS" (2015). Open Access Dissertations. 1312.
https://docs.lib.purdue.edu/open_access_dissertations/1312