Date of Award
January 2016
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Medicinal Chemistry and Molecular Pharmacology
First Advisor
Weiguo A Tao
Committee Member 1
Mark C Hall
Committee Member 2
Robert L Geahlen
Committee Member 3
Chang-Deng Hu
Abstract
The dynamics of post-translational modifications (PTMs) of proteins keeps cells adapting to the ever-changing microenvironment by regulating protein structure and function in the real-time mode. Of all PTMs, protein phosphorylation and glycosylation are undoubtedly two of the most common and important PTMs and have been demonstrated to be closely linked to the onset and progression of various human diseases. Our lab has been focusing on developing novel and more efficient technologies by taking advantage of the properties of dendrimers – a soluble nanopolymer with chemically well-defined structure and functional surface groups – to facilitate the detection and quantification of PTMs using several biochemical assays and mass spectrometry-based shotgun proteomics.
Recommended Citation
Pan, Li, "Development of Dendrimer-based Technologies for Phosphoproteomics and Glycoproteomics in Biomarker Discovery" (2016). Open Access Dissertations. 1265.
https://docs.lib.purdue.edu/open_access_dissertations/1265