Date of Award

January 2016

Degree Type


Degree Name

Doctor of Philosophy (PhD)


Medicinal Chemistry and Molecular Pharmacology

First Advisor

Weiguo A Tao

Committee Member 1

Mark C Hall

Committee Member 2

Robert L Geahlen

Committee Member 3

Chang-Deng Hu


The dynamics of post-translational modifications (PTMs) of proteins keeps cells adapting to the ever-changing microenvironment by regulating protein structure and function in the real-time mode. Of all PTMs, protein phosphorylation and glycosylation are undoubtedly two of the most common and important PTMs and have been demonstrated to be closely linked to the onset and progression of various human diseases. Our lab has been focusing on developing novel and more efficient technologies by taking advantage of the properties of dendrimers – a soluble nanopolymer with chemically well-defined structure and functional surface groups – to facilitate the detection and quantification of PTMs using several biochemical assays and mass spectrometry-based shotgun proteomics.