"STRUCTURAL ELUCIDATION OF DEPROTONATED ANALYTES VIA TANDEM MASS SPECTR" by Hanyu Zhu

Date of Award

January 2016

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

First Advisor

Hilkka I Kenttämaa

Committee Member 1

Garth J Simpson

Committee Member 2

Mary J Wirth

Committee Member 3

Shelley Claridge

Abstract

Mass Spectrometry has emerged as a powerful analytical tool for the characterization of unknown molecules. Molecular weight information and chemical formulas of the unknowns can be derived by measuring the m/z value of the ionized analyte. In addition, structural information can be obtained via tandem mass spectrometry methods such as collision-activated dissociation (CAD). However, CAD does not always guarantee unambiguously assignment of chemical structures, therefore, additional tandem mass spectrometric methods such as ion-molecule reactions were developed.

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