Date of Award
January 2015
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Animal Science
First Advisor
Shihuan Kuang
Committee Member 1
Paul Collodi
Committee Member 2
Ourania Andrisani
Committee Member 3
Henry Chang
Abstract
Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy surplus. Another two types of adipocytes can also be found in human: beige and brown adipocytes. In opposite to white adipocytes, beige and brown adipocytes ameliorate obesity by burning lipids for thermogenesis. Thus, an increase in beige/brown adipocyte content in adipose tissue, termed browning would raise energy expenditure and reduce adiposity.
Recommended Citation
Bi, Pengpeng, "NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM" (2015). Open Access Dissertations. 1200.
https://docs.lib.purdue.edu/open_access_dissertations/1200