Date of Award

January 2015

Degree Type


Degree Name

Doctor of Philosophy (PhD)


Biomedical Engineering

First Advisor

Zheng Ouyang

Committee Member 1

R. Graham Cooks

Committee Member 2

Riyi Shi

Committee Member 3

Young L. Kim


This thesis focuses on the development of miniature mass spectrometry systems and the sampling probes. Mass spectrometers are usually installed and used in the analytical laboratory. It requires complex sample preparation before the analysis. Use of miniature mass spectrometer enables the chemical analysis outside the lab and a sampling probe provides convenience for real-time analysis. Two miniature mass spectrometer systems have been developed in this work.