Date of Award

January 2015

Degree Type


Degree Name

Doctor of Philosophy (PhD)


Chemical Engineering

First Advisor

Carl Laird

Committee Member 1

Zoltan Nagy

Committee Member 2

Gintaras Reklaitis

Committee Member 3

Andrew Liu


Effective manufacturing of pharmaceuticals presents a number of challenging optimization problems due to complex distributed, time-independent models and the need to handle uncertainty. These challenges are multiplied when real-time solutions are required. The demand for fast solution of nonlinear optimization problems, coupled with the emergence of new concurrent computing architectures, drives the need for parallel algorithms to solve challenging NLP problems. The goal of this work is the development of parallel algorithms for nonlinear programming problems on different computing architectures, and the application of large-scale nonlinear programming on challenging problems in pharmaceutical manufacturing.