Date of Award
January 2014
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Hilkka I Kenttämaa
Committee Member 1
Scott A. McLuckey
Committee Member 2
Chengde Mao
Committee Member 3
Yu Xia
Abstract
Due to the high sensitivity, selectivity and speed, mass spectrometry (MS) has proved to be an invaluable tool for mixture analysis and structural elucidation of mixture components. Tandem mass spectrometry (MS/MS) utilizing collision-activated dissociation (CAD) has become the technique of choice for structural elucidation of unknown analytes. The coupling of MS/MS with high performance liquid chromatography (HPLC) has allowed trace level analysis of components in very complex mixtures. Analysis of mixtures of lignin degradation products is a problematic area for mass spectrometry due to the highly complex lignin linkages present. Hence, study of lignin model compounds with varies linkage types is very helpful for the structural elucidation of unnknown lignins. Gas phase ion-molecule reaction can be useful in study of reaction kinetics and mechanism and even in probing the functional groups in unknown molecules. The functional group selective ion-molecule reaction has great potential for unknown drug metabolite identification
Recommended Citation
Sheng, Huaming, "Mass Spectrometric Studies on Lignin Sequencing and Fast Pyrolysis, Functional-Group Selective Ion-Molecule Reactions and Reactivity of Bi- and Triradicals" (2014). Open Access Dissertations. 1068.
https://docs.lib.purdue.edu/open_access_dissertations/1068