Date of Award


Degree Type


Degree Name

Doctor of Philosophy (PhD)



First Advisor

Scott D Briggs

Committee Member 1

Scott D Briggs

Committee Member 2

Joseph P Ogas

Committee Member 3

Ann L Kirchmaier

Committee Member 4

Harry Charbonneau


Gene expression has been shown to be regulated through epigenetic modifications to the N-terminal tail of histones. Among these modifications is methylation of lysine residues. The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue of the human JARID1 family of histone demethylases, which has four members: JARID1A, B, C and D. JARID1B is of particular interest because it has been shown to be up regulated in 90 percent of primary breast cancers. Furthermore, JARID1A has been shown to be up regulated in gastric cancer. Therefore studying how these H3K4 histone demethylases function will give great insight into how JARID1 family members are missregulated during tumorigenesis and how they can be targeted by inhibitors.