Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors
Abstract
We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin BSA and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1/ f noise by 100-fold, resulting in a deflection resolution of 0.065 Å in air.
Keywords
biosensor, sensitivity, cantilever, magnetic, thermomechanical
Date of this Version
9-11-2008
Recommended Citation
Icoz, Kutay; Iverson, Brian D.; and Savran, Cagri, "Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors" (2008). Birck and NCN Publications. Paper 99.
https://docs.lib.purdue.edu/nanopub/99