SERS aptasensor from nanorod-nanoparticle junction for protein detection

Yuling Wang, Purdue University - Main Campus
Kyuwan Lee, Purdue University - Main Campus
Joseph Irudayaraj, Purdue University - Main Campus

Date of this Version


This document has been peer-reviewed.



A multicomponent nanostructure comprising of gold nanorod-nanoparticle (AuNR-AuNP) composites was fabricated to detect thrombin at subnanomolar concentrations in diluted human blood serum. Simulation and experiments revealed that the strong electromagnetic coupling resonance at the nanorod-nanoparticle junction of these probes can be used to construct highly sensitive SERS aptasensors.


Engineering | Nanoscience and Nanotechnology