Characterization of vaccinia virus particles using microscale silicon cantilever resonators and atomic force microscopy

Author

• Luke Johnson, Department of Physics, Luther College; Weldon School of Biomedical Engineering, Purdue University
• Amit Kumar Gupta, Birck Nanotechnology Center, Bindley Bioscience Center, School of Electrical and Computer Engineering, and the Weldon School of Biomedical Engineering, Purdue UniversityFollow
• Azam Ghafoor, Birck Nanotechnology Center, Bindley Bioscience Center, School of Electrical and Computer Engineering, and the Weldon School of Biomedical Engineering, Purdue UniversityFollow
• Demir Akin, Birck Nanotechnology Center, Bindley Bioscience Center, School of Electrical and Computer Engineering, and the Weldon School of Biomedical Engineering, Purdue UniversityFollow
• Rashid Bashir, Birck Nanotechnology Center, Bindley Bioscience Center, School of Electrical and Computer Engineering, and the Weldon School of Biomedical Engineering, Purdue UniversityFollow

Abstract

Rapid means of characterizing and detecting virus particles are very important for a wide variety of applications. We have used vaccinia virus, a member of the Poxviridae virus family and the basis of the smallpox vaccine, as the test case and characterized these particles using atomic force microscopy and micron-scale cantilever beams, with the long-term goal of developing devices for the direct rapid detection of air-borne virus particles. The cantilever beams, driven by thermal noise and a PZT piezoelectric ceramic, served as resonating sensors to measure the mass of these virus particles. Two different size cantilevers were used, with dimensions of 21

Comments

doi:10.1016/j.snb.2005.08.047

Keywords

BioMEMS; Cantilever sensors; Resonant sensors

Date of this Version

10-13-2005

Recommended Citation

Johnson, Luke; Gupta, Amit Kumar; Ghafoor, Azam; Akin, Demir; and Bashir, Rashid, "Characterization of vaccinia virus particles using microscale silicon cantilever resonators and atomic force microscopy" (2005). Birck and NCN Publications. Paper 24.
https://docs.lib.purdue.edu/nanopub/24