Fluorogenic transformations based on formation of C-C bonds catalyzed by palladium: An efficient approach for high throughput optimizations and kinetic studies

Author

• Roman V. Rozhkov, Purdue UniversityFollow
• Vincent J. Davisson, Purdue UniversityFollow
• Donald E. Bergstrom, Birck Nanotechnology Center and Bindley Bioscience Center, Purdue UniversityFollow

Abstract

We have developed novel fluorogenic transformations based on formation of C-C bonds catalyzed by palladium using iodocoumarin I as a model aryl iodide, where fluorescence is quenched completely due to effects of the heavy, polarizable iodine atom. Substitution of the iodine atom for the carbon using Sonogashira, Suzuki-Miyaura and Heck couplings results in a dramatic fluorescence enhancement. This approach has been used successfully for the optimization of reaction conditions and kinetic studies in high throughput format.

Date of this Version

1-1-2008

Recommended Citation

Rozhkov, Roman V.; Davisson, Vincent J.; and Bergstrom, Donald E., "Fluorogenic transformations based on formation of C-C bonds catalyzed by palladium: An efficient approach for high throughput optimizations and kinetic studies" (2008). Birck and NCN Publications. Paper 206.
https://docs.lib.purdue.edu/nanopub/206