Abstract
While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.
Keywords
nanomedicine, nanoparticles, multimodal imaging, CT, MRI, NIRF, PET, cancer, RAY COMPUTED-TOMOGRAPHY, UP-CONVERSION LUMINESCENCE, IRON-OXIDE NANOPARTICLES, MRI CONTRAST AGENTS, MAGNETIC NANOPARTICLES, GOLD NANOPARTICLES, MULTIFUNCTIONAL NANOPARTICLES, INORGANIC NANOPARTICLES, CHITOSAN NANOPARTICLES, BLADDER CANCER
DOI
10.2147/IJN.S53717
Date of this Version
2014
Recommended Citation
Key, Jaehong and Leary, James F., "Nanoparticles for multimodal in vivo imaging in nanomedicine" (2014). Birck and NCN Publications. Paper 1530.
http://dx.doi.org/10.2147/IJN.S53717
Comments
This is the Publisher PDF of Key, J and Leary, JF. "Nanoparticles for multimodal in vivo imaging in nnomedicine." International Journal of Nanomedicine, 9(1):711-726. 2014. Published by Dove Press, it is made available here with a CC-BY-NC license and is also available at http://dx.doi.org/10.2147/IJN.S53717.