Reflective Diffraction Gratings From Hydrogels as Biochemical Sensors
Abstract
We report reflective diffraction gratings made from smart hydrogels for ultrasensitive biochemical detection. As an example for a stimuli-responsive hydrogel, we chose a pH-sensitive hydrogel to construct diffraction gratings that swell/shrink reversibly due to changes in pH. Interferometric analysis of the grating enabled detection of the hydrogel's motions with nanoscale precision and resulted in a resolution of 6 x 10(-4) pH units. The developed system is remarkably simple both to fabricate and operate, and yet extremely sensitive. Moreover, the concept of the reflective hydrogel grating is generic and can be applied detection of a wide range of other stimuli.
Keywords
Biochemical sensors; diffraction; gratings; smart hydrogels; ANTIGEN-RESPONSIVE HYDROGEL; GLUCOSE-OXIDASE; PH; CANTILEVER
DOI
10.1109/JSEN.2012.2189382
Citation
Reflective Diffraction Gratings From Hydrogels as Biochemical Sensors Chun-Li Chang; Zhenwen Ding; Venkata N. L. R. Patchigolla; Babak Ziaie; Cagri A. Savran IEEE Sensors Journal Year: 2012, Volume: 12, Issue: 7 Pages: 2374 - 2379
Date of this Version
7-2012
Recommended Citation
Chang, Chun-Li; Ding, Zhenwen; Patchigolla, Venkata N. L. R.; Ziaie, Babak; and Savran, Cagri A., "Reflective Diffraction Gratings From Hydrogels as Biochemical Sensors" (2012). Birck and NCN Publications. Paper 1173.
http://dx.doi.org/10.1109/JSEN.2012.2189382