Polymeric microdevices for transdermal and subcutaneous drug delivery
Abstract
Low cost manufacturing of polymeric microdevices for transdermal and subcutaneous drug delivery is slated to have a major impact on next generation devices for administration of biopharmaceuticals and other emerging new formulations. These devices range in complexity from simple microneedle arrays to more complicated systems incorporating micropumps, micro-reservoirs, on-board sensors, and electronic intelligence. In this paper, we review devices currently in the market and those in the earlier stages of research and development. We also present two examples of the research in our laboratory towards using phase change liquids in polymeric structures to create disposable micropumps and the development of an elastomeric reservoir for MEMS-based transdermal drug delivery systems. (C) 2012 Elsevier B.V. All rights reserved.
Keywords
Polymeric microdevices; BioMEMS; Microfluidics; Transdermal drug delivery; Micropumps; MICROFLUIDIC SYSTEMS; PEN-INJECTORS; IN-VIVO; MICRONEEDLES; FABRICATION; MICROPUMP; DEVICES; ACCURACY; SYRINGES; ARRAYS
DOI
10.1016/j.addr.2012.09.035
Citation
Advanced Drug Delivery Reviews Volume 64, Issue 14, November 2012, Pages 1603–1616
Date of this Version
11-2012
Recommended Citation
Ochoa, Manuel; Mousoulis, Charilaos; and Ziaie, Babak, "Polymeric microdevices for transdermal and subcutaneous drug delivery" (2012). Birck and NCN Publications. Paper 1100.
http://dx.doi.org/10.1016/j.addr.2012.09.035