Silicon Field Effect Transistors as Dual-Use Sensor-Heater Hybrids

Author

• Bobby Reddy Jr., University of Illinois Urbana-Champaign
• Oguz H. Elibol, Birck Nanotechnology Center, Purdue University
• Pradeep R. Nair, Birck Nanotechnology Center, Purdue UniversityFollow
• Brian R. Dorvel, University of Illinois Urbana-Champaign
• Felice Butler, University of Illinois Urbana-Champaign
• Zahab S. Ahsan, Purdue University; University of Illinois Urbana-ChampaignFollow
• Donald E. Bergstrom, Birck Nanotechnology Center, Purdue UniversityFollow
• Muhammad A. Alam, Birck Nanotechnology Center, Purdue UniversityFollow
• Rashid Bashir, University of Illinois at Urbana-ChampaignFollow

Abstract

We demonstrate the temperature mediated applications of a previously proposed novel localized dielectric heating method on the surface of dual purpose silicon field effect transistor (FET) sensor-heaters and perform modeling and characterization of the underlying mechanisms. The FET's are first shown to operate as electrical sensors via sensitivity to changes in pH in ionic fluids. The same devices are then demonstrated as highly localized heaters via investigation of experimental heating profiles and comparison to simulation results. These results offer further insight into the heating mechanism and help determine the spatial resolution of the technique. Two important biosensor platform applications spanning different temperature ranges are then demonstrated: a localized heat mediated DNA exchange reaction and a method for dense selective functionalization of probe molecules via the heat catalyzed complete desorption and reattachment of chemical functionalization to the transistor surfaces. Our results show that the use of silicon transistors can be extended beyond electrical switching and field-effect sensing to performing localized temperature controlled chemical reactions on the transistor itself.

Keywords

MICROFLUIDIC DEVICE; CELL-LYSIS; PCR; DNA; AMPLIFICATION; PROTEINS; FUNCTIONALIZATION; NANOWIRES

DOI

10.1021/ac102566f

Citation

Anal. Chem., 2011, 83 (3), pp 1144–1147

Date of this Version

2-1-2011

Recommended Citation

Reddy, Bobby Jr.; Elibol, Oguz H.; Nair, Pradeep R.; Dorvel, Brian R.; Butler, Felice; Ahsan, Zahab S.; Bergstrom, Donald E.; Alam, Muhammad A.; and Bashir, Rashid, "Silicon Field Effect Transistors as Dual-Use Sensor-Heater Hybrids" (2011). Birck and NCN Publications. Paper 1058.
http://dx.doi.org/10.1021/ac102566f