Gold Nanorod-Mediated Photothermolysis Induces Apoptosis to Macrophages via Damage of Mitochondria

Author

Ling Tong, Department of Chemistry, Purdue UniversityFollow
Ji-Xin Cheng, Department of Chemistry, Weldon School of Biomedical Engineering, Purdue UniversityFollow

Abstract

Alterations in macrophage functions contribute to a variety of autoimmune and inflammatory diseases. Diagnosis and eradication of activated macrophages is becoming a valid pharmaceutical target. In this work, gold nanorods conjugated with arginine-rich peptides were applied as theragonosis agents to detect activated macrophages via two-photon luminescence (TPL) and subsequent eradicate through optical hyperthermia. Functionalized gold nanorods could be selectively internalized by activated macrophages in live animals 0.5 h after intraperitoneal (i.p.) injection. Apoptosis of macrophage was induced under proper irradiation conditions to reduce secondary inflammation, through mitochondria-dependent pathway.

Comments

Poster for 2008 BNC Research Review

Date of this Version

4-17-2008

Recommended Citation

Tong, Ling and Cheng, Ji-Xin, "Gold Nanorod-Mediated Photothermolysis Induces Apoptosis to Macrophages via Damage of Mitochondria" (2008). Birck Poster Sessions. Paper 23.
https://docs.lib.purdue.edu/nanoposter/23