Abstract
Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.
Keywords
CANCER; NANOPARTICLES; THERAPY; ABSORPTION; GROWTH; RADIATION; CLUSTERS; LIGHT; SHAPE; SIZE
Date of this Version
10-2007
Included in
Biomedical Engineering and Bioengineering Commons, Nanoscience and Nanotechnology Commons