Abstract
Folate-conjugated gold nanorods targeted to tumor cell surfaces produced severe membrane damage upon near-infrared irradiation. Photoinduced injury to the plasma membrane resulted in a rapid increase in intracellular calcium (shown in green) with subsequent disruption of the actin network, featured prominently by the formation of membrane blebs.
Keywords
CANCER; NANOPARTICLES; THERAPY; ABSORPTION; GROWTH; RADIATION; CLUSTERS; LIGHT; SHAPE; SIZE
Date of this Version
10-2007
Recommended Citation
Tong, Ling; Zhao, Yan; Huff, Terry B.; Hansen, Matthew N.; Wei, Alexander; and Cheng, Ji-Xin, "Gold nanorods mediate tumor cell death by compromising membrane integrity" (2007). Other Nanotechnology Publications. Paper 158.
https://docs.lib.purdue.edu/nanodocs/158
Included in
Biomedical Engineering and Bioengineering Commons, Nanoscience and Nanotechnology Commons