Recommended Citation
Sun, Ruoxuan; Kim, Alyssa Min Jung; and Lim, Seung-Oe, "Glycosylation of Immune Receptors in Cancer" (2021). Purdue University Libraries Open Access Publishing Fund. Paper 150.
http://dx.doi.org/10.3390/cells10051100
DOI
10.3390/cells10051100
Date of this Version
5-4-2021
Keywords
glycosylation, N-glycan, immune receptor, immune checkpoint therapy, cancer
Abstract
Evading host immune surveillance is one of the hallmarks of cancer. Immune checkpoint therapy, which aims to eliminate cancer progression by reprogramming the antitumor immune response, currently occupies a solid position in the rapidly expanding arsenal of cancer therapy. As most immune checkpoints are membrane glycoproteins, mounting attention is drawn to asking how protein glycosylation affects immune function. The answers to this fundamental question will stimulate the rational development of future cancer diagnostics and therapeutic strategies.
Comments
This is the publisher PDF of Sun, R.; Kim, A.M.J.; Lim, S.-O. Glycosylation of Immune Receptors in Cancer. Cells 2021, 10, 1100. This article is distributed under a CC-BY license, and is available at DOI: 10.3390/cells10051100.