Role of acetyl-CoA carboxylase in glucose-induced insulin secretion in pancreatic beta-cell
Abstract
Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to produce malonyl-CoA, the most important rate limiting reaction for lipogenesis. In the first part of the present study, first direct evidence is presented on (1) ACC controls fatty acid oxidation; (2) ACC serves as fuel sensor of pancreatic $\beta$-cells which integrates action of all classes of nutrient secretagogues to stimulate insulin secretion. In the second part, the molecular mechanisms by which the ACC gene is regulated are dissected.
Degree
Ph.D.
Advisors
Kim, Purdue University.
Subject Area
Biochemistry|Molecular biology|Nutrition|Cellular biology
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