Improvements in post-column reaction technology for microbore liquid chromatography
Abstract
A post-column reactor suitable for use with microbore liquid chromatography was developed. The choice for the post-column derivatization system was on-line photolysis, since it is does not require any mixing of the column effluent which might cause added band-spreading. The geometry of the reaction tubing was studied, and a knitted reactor design was shown to exhibit the best flow characteristics. An open-tubular reactor was created and tested with the detection of phenylalanine. In order to enhance the performance of this type of reactor, TiO$\sb2$ was utilized as a catalyst to improve the rate of the photolytic reaction and the product yield.
Degree
Ph.D.
Advisors
Kissinger, Purdue University.
Subject Area
Analytical chemistry
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