Irreversible adsorption of macromolecules at the solid-liquid interface: Simulation and theory
Abstract
The adsorption of large particles like proteins, bacteria, viruses, enzymes and latexes from solution onto solid surfaces is of great significance in many practical applications which include chromatographic separation, water cleansing, biosensors and blood clotting induced by artificial organs. Despite the importance of this field, the development of quantitative descriptions is still at the beginning stage. The main reason is that the adsorption process of above examples is irreversible for a wide range of conditions. Thus, a fundamental approach which considers many-body and memory effects is necessary for an accurate description of the adsorption kinetics and the structure of the adsorbed layer. The first three chapters consider several stochastic models which basically take into account the above two effects. In Chapter 2, the rolling mechanisms of simple ballistic deposition (BD) model are clarified and, consequently, the asymptotic kinetics of the model is found. In Chapter 3, random sequential adsorption (RSA) and ballistic deposition models are encompassed as special cases by the generalized ballistic deposition (GBD) model. The kinetics of the model are analyzed theoretically and compared with the results of computer simulations. In Chapter 4, the critical exponents $\beta$, $\gamma$, $\nu$ of the model are determined by finite size scaling and Monte Carlo renormalization group techniques and are shown to be consistent with those of ordinary 2D lattice percolation. The following five chapters consider the influence of various forces on the kinetics and the structure of particle deposits. In Chapter 5, it is demonstrated that the Brownian force of particle dynamics results in the non-uniform distribution of particle deposits. In Chapter 6 and 7, the influence of gravity relative to Brownian force on the formation of the first layer of particle deposits is systematically studied for both 1+1 and 2+1 D models. In Chapter 8, the effect of hydrodynamic interactions on the kinetics and the structure of particle deposits is investigated for two different systems: Brownian particles and large particles, $N\sb{G}=\infty$. In Chapter 9, colloidal interactions are added to hydrodynamic interactions and gravity to show their influence on the dynamics and the configuration of particle deposits.
Degree
Ph.D.
Advisors
Talbot, Purdue University.
Subject Area
Chemical engineering|Biophysics|Chemistry
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