Approaches toward the total synthesis of cytochalasin C
Abstract
The total synthesis of cytochalasin C was attempted. The key feature of this strategy required the synthesis of a seven membered ring exocyclic olefin that would be the fragmentation precursor to the macrocyclic eleven membered ring present in cytochalasin C. This study described the development of methodology to obtain related, model, exocyclic olefins to this end. However, application of this strategy was not realized at the expense of achieving the C$\sb{9,21}$ bond connection.
Degree
Ph.D.
Advisors
Fuchs, Purdue University.
Subject Area
Organic chemistry
Off-Campus Purdue Users:
To access this dissertation, please log in to our
proxy server.