Pathogenesis and immunopathology of sarcoptic mange in pigs
Abstract
Sarcoptic mange of pigs is a disease caused by the invasion of the skin by Sarcoptes scabiei var. suis. This disease is common in pigs and can occur wherever these animals are raised. One of the basic features of mange lesions is that they develop to maximum intensity and then regress. This sequence of events alludes to the possibility that the host may develop an immunological response to the infestation and consequently inhibit the growth of the mite population. Clinical, pathological and immunopathological investigations were conducted to measure the rate of development of sensitization to the mite invasion, and to determine how this sensitization contributes to the pathogenesis of the disease. The results of a single infestation, multiple infestations as well as the influence age on the sequence of the development of the disease will be presented. Using scanning electron microscopy to study the progression and regression of scabies lesions revealed three different stages through the course of the disease. The use of immunofluorescence and immunoperoxidase techniques showed gradual but marked increase in numbers of the immunoglobulin secreting cells in the skin during development of the lesions. This was followed by marked decrease as the lesions regressed. This rise and fall in numbers of immunoglobulin secreting cells were observed in all three phases of the investigations.
Degree
Ph.D.
Advisors
Gaafar, Purdue University.
Subject Area
Veterinary services
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