The use of silicone-cellulose dispersions as vehicles for topical drug delivery
Abstract
It has been recognized that controlled delivery of systemically active agents to the skin for topical absorption may lead to effective control of drug blood levels. Film forming dispersions of cellulose derivatives and liquid silicone polymers were developed as vehicles for the controlled delivery of pharmocologically active agents to the skin. Coherent free films which consisted of over 70.0 percent silicone fluid could be cast from the liquid dispersions. Their potential for providing unique and therapeutically advantageous patterns of drug release was examined. Franz diffusion cells were used in studying the release of incorporated model active ingredients from the cast free films. The effects of silicone content variation and changes in silicone fluid chemical structure on the patterns of drug release from the solid dispersions were monitored and tested for significance. The performance of the delivery system during topical application was also tested through the use of an in vitro animal skin model. The relationship between the physical properties of the silicone-cellulose films and their polymer composition was also characterized. The patterns of release of active ingredients which had been incorporated in the cast films exhibited significant changes when the amount and/or type of silicone polymer comprising the formulations was altered. The physical properties of the films were also affected by these formulation variables. Both the rate and extent of passage of benzocaine from applied free films through hairless mouse skin were altered by the type of silicone fluid which they contained. It was found that cellulose derivative films which are modified by the addition of silicone fluids have potential for use as topical controlled drug delivery systems. Fluid silicone polymers are available with a variety of attached functional groups which allow manipulation of the patterns of drug release by the silicone-cellulose dispersions.
Degree
Ph.D.
Advisors
Peck, Purdue University.
Subject Area
Pharmaceuticals
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