PHARMACOKINETIC IMPULSE RESPONSE ANALYSIS OF INDOCYANINE GREEN IN THE RABBIT
Abstract
Methods were developed to analyze the nonlinear pharmacokinetics of indocyanine green in the rabbit. From the results of these methods, specific functionals were identified which were used to provide predictions of the time course of indocyanine green resident in the rabbit during constant rate infusions. These methods were repeated in five rabbits with infusion predictions obtained for various infusions. The results provided predictions of the time course of indocyanine green resident in the blood stream during sixty minute infusions in the rabbit without the need to adopt any mathematical structure thought to be specific for indocyanine green. These methods represent an extension of impulse response methodology currently used during characterization of linear pharmacokinetic disposition. The results confirmed the nonlinear pharmacokinetic behavior of indocyanine green and demonstrated that functionals could be found from impulse response experiments which would provide predictive information associated with a pharmacokinetically nonlinear behaving system.
Degree
Ph.D.
Subject Area
Pharmaceuticals
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