PHYSICOMECHANICAL CHARACTERIZATION AND FORMULATION OF NATURAL, MODIFIED NATURAL, AND SYNTHETIC POLYMERS INCLUDING POLYMER SALT AND ESTER DERIVATIVES AS ORAL BIOADHESIVE MATERIALS (INSTRON)
Abstract
The physicomechanical in-vitro stress-strain analyses of powder, cream, and gel forms of the various poly (vinyl methyl ether/maleic anhydride) salt, esters and ester-salt compositions were conducted using an Instron Universal Testing Instrument and a special in-vitro test appliance. The maximum adhesional force and the maximum compressional force were determined from the continuously recorded stress-strain profiles. These parameters were used as a basis of comparing the potential values of various polymeric products as denture stabilizers. The effects of polymer composition, polymer blending, test conditions and other factors were determined from the recorded adhesional and compressional force profiles. These aforementioned stress-strain analyses were performed on commercial products as well as experimental formulations. The in-vitro Instron stress-strain analyses were modified to examine different oral bioadhesives under cyclical deformation conditions which simulated the masticatory movements of the mouth. The Instron analyses were conducted with the test sample being exposed to an aqueous test environment composed of a simulated salivary solution, while the test was operated in a continuous cycling mode over extended operating periods. The application of the Instron methodology was found to provide solid, quantitative, mechanical information which could provide the rational development of an oral bioadhesive, the development of which, heretofor, has been purely qualitative.
Degree
Ph.D.
Subject Area
Materials science|Dental care
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