EXPERIMENTAL VERIFICATION OF THE SOLID-LIQUID INTERFACIAL CONCENTRATION DEVELOPED DURING INTERFACIALLY CONTROLLED DISSOLUTION OF A SOLID
Abstract
Dissolution of organic compounds from fused discs was examined using two different dissolution models under static and stirred conditions. A column dissolution model, representing interfacially controlled conditions, was utilized to determine an effective interfacial concentration, less than saturation, characteristic of each compound. The interfacial concentration developed under column dissolution conditions was then verified by a unique dissolution rate versus solubility plot derived from data generated in a vessel dissolution model. In all cases, the respective interfacial concentration derived was significantly less than the compound's saturation solubility. In addition, further evidence to support the previously reported use of a random walk model with auto correlation to describe the concentration gradient developed in a descending column model is given. Additional evidence for the diffusivity equation describing ascending column dissolution is presented.
Degree
Ph.D.
Subject Area
Pharmaceutical sciences
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