Tumor respiratory motion control in radiation therapy
Abstract
Tumor motion induced by patient breathing during treatment delivery has been observed in thoracic and abdominal regions by multiple studies. The maximum tumor motion can be up to 3-4 cm. Tumor motion may lead to significant discrepancy between planned and delivered treatments. In this dissertation, both translational and rotational tumor motion effect in photon and proton radiation therapy treatment were investigated. First, it was demonstrated that target rotation can be detected and corrected in real-time in an integrated radiotherapy system with electromagnetic tracking. Both geometric and dosimetric accuracy of treatment delivery were quantified. Second, a dual-gated VMAT concept was developed and implemented to double the radiation treatment efficiency. Third, dosimetric effect of tumor rotational motion was investigated in proton therapy. In addition, proton applications related to Brachytherapy (HDR and LDR) were explored with consideration of tumor motion. In short, control of tumor motion effect was successfully implemented by different methodologies.
Degree
Ph.D.
Advisors
Stantz, Purdue University.
Subject Area
Medicine|Oncology
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