Studies towards the synthesis of neuraminidase inhibitors and stereoselective synthesis of the C21-C34 subunit of aplyronines
Abstract
A short, enantioselective synthesis of tamiflu was achieved via Shibasaki's 3rd generation intermediate. A practical approach to isotamiflu and isotamiphosphor are described. A convenient approach to convert tamiflu to its more potent counterpart, tamiphosphor was achieved. The C28-C33 subunit of Aplyronine A, containing four stereocenters, was prepared using vinyl sulfone chemistry.
Degree
Ph.D.
Advisors
Fuchs, Purdue University.
Subject Area
Chemistry|Organic chemistry
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