Bioadhesive polymeric drug delivery systems for tumor targeting and tissue repair
Abstract
A drug delivery system refers to a dosage form that is able to control or modify the availability of the active ingredient to the body due to its construction as well as temporal or spatial arrangement. An efficient drug delivery system should localize treatment to diseased cells or the site of injury. This can be achieved by increasing the adhesion of the drug delivery vehicle to biological surfaces of interest, such as specific cells or tissues. Enhanced adhesion can ultimately increase drug residence time, concentration, and absorption by target tissues. I explored such benefits of enhanced adhesion in two contexts: tumor targeted drug delivery and tissue repair. ^ This thesis is divided into two chapters. Chapter1 describes tumor targeted drug delivery by nanoparticulated systems and is subdivided to Part 1—Quinic acid conjugated nanoparticles for tumor specific therapy and Part 2—pH-responsive and stealth chitosan coated nanoparticles for tumor therapy. Chapter 2 describes bioadhesive hydrogels for tissue repair.^
Degree
Ph.D.
Advisors
Yoon Yeo, Purdue University.
Subject Area
Engineering, Biomedical|Health Sciences, Pharmacy
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