Development of DIPHOS(O) as a bis -Horner reagent and model studies towards the synthesis of C12–C23 polyene fragment of rhizoxin D
Abstract
Bisphosphorane reagents, useful for the synthesis of conjugated polyenes, have not been extensively utilized. We have developed bis(diphenylphosphine) ethane monoxide DIPHOS(O) as a bisphosphorane reagent which leads to an asymmetric conjugated diene via a double Homer olefination reaction. The details and model studies on the application of DIPHOS(O) towards the synthesis of Rhizoxin D is discussed.
Degree
Ph.D.
Advisors
Fuchs, Purdue University.
Subject Area
Organic chemistry
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