Progress toward the total synthesis of (−)-homoharringtonine

Sunghoon Ma, Purdue University

Abstract

Progress toward the total synthesis of (−)-homoharringtonine via vinyl sulfone methodology is described herein. Three major projects are involved in this area: (1) Conversion of vinyl sulfones to regiospecifically functionalized trisubstituted olefins; (2) Efficient syntheses of enantiopure five carbon segments employing 3-phenylsulfonyl cyclopentene; (3) Synthetic studies toward total synthesis of the (−)-Cephalotaxine core and side chains.

Degree

Ph.D.

Advisors

Fuchs, Purdue University.

Subject Area

Organic chemistry

COinS