A wireless, passive pressure sensor for measuring interstitial fluid pressure with a Guyton chamber
Abstract
In this study, a wireless interstitial fluid pressure sensor incorporating a perforated capsule first introduced by A. C. Guyton was designed, fabricated, and tested. The Guyton capsule allowed for an accurate measurement of interstitial fluid pressure (IFP) without the interference from various cellular components by permitting the interstitial fluid to penetrate the chamber after implantation. This device was designed for use as an implantable pressure sensor for noninvasive and chronic measurements IFP in tumors. The sensor consists of a coil, an air chamber, a silicone membrane embedded with a nickel plate, and a Guyton capsule. The fabricated device was 6 mm in diameter and 1 mm in thickness. Being biocompatible, the materials' properties along with the device's design allowed for the accurate measurements of pressure with a sensitivity of 16.0 kHz/mmHg in air and 25.0 kHz/mmHg in water. This device successfully measured values of pressure from -6 mmHg to 32 mmHg, which was the target range for use in measuring IFP in tumors.
Degree
M.S.M.E.
Advisors
Ziaie, Purdue University.
Subject Area
Biomedical engineering|Electrical engineering|Mechanical engineering
Off-Campus Purdue Users:
To access this dissertation, please log in to our
proxy server.