Diffusion weighted imaging in auditory functional magnetic resonance imaging
Abstract
The use of diffusion-weighted imaging in functional MRI requires proper implementation of a twice-refocused spin echo (TRSE) pulse sequence to reduce noise induced by eddy currents. An existing TRSE-capable pulse sequence was used to evaluate the possibility of detecting activation in auditory cortex to an auditory stimulus using diffusion-weighted fMRI. No activation was detected, possibly due to inadequacies of the pulse sequence used. This further increased the need for a custom TRSE implementation. TRSE capabilities were added to a different pulse sequence; one that was designed to allow more accurate detection of auditory activation in a noisy MRI environment. The optimization of this sequence was begun, limited by deficiencies in the EPI readout capabilities. Proper optimization of this sequence in the future should allow it to be used to detect brain function in response to auditory stimuli.
Degree
M.S.E.C.E.
Advisors
Talavage, Purdue University.
Subject Area
Biomedical engineering|Electrical engineering
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